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KMID : 1123920050190010184
Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 1 p.184 ~ p.190
Effect of Germinated Seed of Rhynchosia Volubilis on Cathepsin-K in Ovariectomized Rats
Jung Ho-Long

Cha Yun-Yeop
Lee Eung-Se
Abstract
The aim of this study is to find out what inhibition effects the Germinated Seed of Rhynchosia Volubilis(GSRV) has by its feeding period on the bone absorption in ovariectomized white rats. Close examination of the amounts of the Cathepsin-K in the rats by the groups of one, two and three-day germination periods led to the following conclusions. Feeding non-ovariectomized white rats with GSRV by the groups of one, two and three-day germination periods showed less amounts of Cathepsin-K in their proximal tibia in all the feeding periods of two, three and four weeks than in the case of control group, revealing a statistical significance. Feeding ovariectomized white rats with GSRV by the groups of one, two and three-day germination periods showed less amounts of Cathepsin-K in their proximal tibia in all the feeding periods of two, three and four weeks than in the case of the control group, revealing a statistical significance. Therefore, the Germinated Seed of Rhynchosia Volubilis(GSRV) is believed to have inhibition effects on bone resorption.
KEYWORD
Rhynchosia Volubilis, Cathepsin-K, Osteoporosis, bone resorption
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